First quarter of 2006: Sales growth of 9.6% on a reported basis and 4.9% on a comparable basis. 52.8% growth in adjusted EPS and 19.8% excluding selected items.

PARIS, May 5 /PRNewswire-FirstCall/ -- The consolidated income statement for the first quarter of 2006 is provided in the appendices. 2006 first- quarter consolidated net income came to euro 1,512 million, compared to euro 531 million for the first quarter of 2005, after the post-tax impact of the accounting treatment of the Aventis acquisition and restructuring costs (euro 661 million in Q1 2006, euro 884 million in Q1 2005).
In order to give a better representation of our underlying economic performance, we have decided to publish and explain an adjusted consolidated income statement(1) for the first quarter of 2006, and compare it with an adjusted income statement for the first quarter of 2005. Adjusted net income for the first quarter of 2006 amounted to euro 2,173 million, against euro 1,415 million for the first quarter of 2005.
Unless otherwise indicated, all sales growth figures in this press release are stated on a comparable basis(1).
FIRST QUARTER

Good sales growth despite the introduction of generics of 4 products(2)
-- Net sales: euro 7,035 million, up 4.9% (9.6% on a reported basis).
Excluding the impact of the introduction of generics of 4 products(2)
in the United States in the second half of 2005, sales growth would
have been 10.4%
-- Strong performance by the Vaccines business: net sales up 30.9%
-- Developed sales: up 6.8%

Adjusted EPS up 52.8% at euro 1.62 (vs. euro 1.06 for Q1 2005), and up 19.8% excluding selected items(3)
-- R&D expenses up by 13.3%
-- "Operating income - current" up 12.9% at euro 2,419 million
-- 53.6% growth in adjusted net income to euro 2,173 million
-- Selected items include a gain on the disposal of Exubera(R) of euro
384 million after tax

LAUNCH OF PLAVIX IN JAPAN
Plavix(R) is due to be launched in Japan in May 2006.

ACOMPLIA(R) RECOMMENDED FOR APPROVAL IN THE EUROPEAN UNION
for the following indication: " As an adjunct to diet and exercise for the treatment of obese patients (BMI greater than or equal to 30kg/m2), or overweight patients (BMI > 27 kg/m2) with associated risk factors, such as type 2 diabetes or dyslipidemia(4)
(1) Refer to the appendices for definitions of financial indicators
(2) Allegra(R), Amaryl(R), Arava(R) and DDAVP(R) in the United States
(3) See Appendix 5
(4) Importantly, statements in Section 5.1 of the Summary of Product
Characteristics stipulate that half of the observed improvements in
HbA1c, HDL cholesterol and triglycerides were beyond that expected
from weight loss alone

FIRST-QUARTER RESULTS CONFIRM 2006 FULL-YEAR GUIDANCE

2006 first-quarter net sales
In the first quarter of 2006, sanofi-aventis posted net sales of euro 7,035 million, up 4.9%. Exchange rate movements had a favorable effect of 5.4 points, around two-thirds of which was due to the rise in the US dollar. Changes in Group structure had a negative effect of 0.7 of a point. After allowing for these impacts, reported-basis growth was 9.6%.
Net sales by business segment
Net sales reported by sanofi-aventis comprise net sales generated by the pharmaceuticals business and net sales generated by the human vaccines business.
Pharmaceuticals
First-quarter net sales for the pharmaceuticals business, which were significantly affected by the introduction of Allegra(R) generics in the United States in September 2005, rose by 3.3% to euro 6,523 million. Net sales of the top 15 products were up 7.6% at euro 4,265 million, representing 65.4% of pharmaceuticals net sales, against 62.8% for the same period in 2005. Excluding the impact of generics of Allegra(R) and Amaryl(R) in the United States, the top 15 products would have achieved growth of 15.4%.
euro million Q1 2006 Change on a
net sales comparable basis
Lovenox(R) 624 +16.4%
Plavix(R) 580 +21.1%
Stilnox(R)/Ambien(R)/Ambien CR(TM) 441 +11.9%
Taxotere(R) 430 +11.1%
Eloxatin(R) 429 +15.0%
Lantus(R) 382 +42.0%
Copaxone(R) 263 +30.8%
Aprovel(R) 248 +15.9%
Tritace(R) 235 +2.2%
Allegra(R) 180 -56.4%
Amaryl(R) 121 -26.2%
Xatral(R) 94 +14.6%
Actonel(R) 89 +23.6%
Depakine(R) 78 +2.6%
Nasacort(R) 71 -4.1%
TOTAL TOP 15 4,265 +7.6%
TOTAL excluding impact of
Allegra(R) and Amaryl(R) in the USA * 4,179 +15.4%

* Excluding net sales of Allegra(R) and Amaryl(R) in the United States

First-quarter net sales of other pharmaceutical products were down 4.0% at euro 2,258 million. This fall was mainly due to the introduction of generics of DDAVP(R) (down 79.2%) and Arava(R) (down 96.8%) in the United States, and to price cuts. Excluding the impact of generics(5) of these two products, net sales of other pharmaceutical products would have declined by just 1.1%.
Human vaccines
First-quarter consolidated net sales for the Human Vaccines business were up 30.9% at euro 512 million.
Sales were lifted by the success of Menactra(R) and Adacel(TM). Menactra(R), on sale in the United States since March 2005, achieved net sales of euro 53 million. Sales of Adacel(TM) (adult tetanus-diphtheria-whooping cough-Tdap booster), launched in the United States in July 2005, came to euro 31 million, and were helped by an extension of the vaccination recommendations issued by ACIP in the final quarter of 2005.
Sales of Decavac(R) (preservative-free adult booster against diphtheria and tetanus), launched in the United States in January 2005, came to euro 33 million.
2006 first-quarter sales of influenza vaccines were euro 72 million, a rise of 30.9%. Sales were boosted by a strong vaccination season in the southern hemisphere, and by an extension of the vaccination season in the United States. The first-quarter figures do not include any sales of H5N1 vaccines in the United States.
(5) Excluding U.S. net sales of Arava(R) and DDAVP(R)

euro million Q1 2006 Change on a
net sales comparable basis
Polio/Whooping Cough/Hib Vaccines 185 +20.1%
Adult Booster Vaccines 81 +11.0%
Influenza Vaccines 72 +30.9%
Travel Vaccines 67 +81.1%
Meningitis/Pneumonia Vaccines 64 +128.6%
Other vaccines 43 -2.3%
TOTAL 512 +30.9%


Sanofi Pasteur MSD, the joint venture with Merck & Co in Europe, generated first-quarter sales of euro 144 million, up 12.5% on a reported basis. This strong growth was driven by fine performances from adult booster vaccines and the measles/mumps/rubella range. Excluding Hexavac(R), sales of which were suspended by the EMEA in September 2005, Sanofi Pasteur MSD would have posted sales growth of 35.3% on a reported basis.
These sales are not consolidated by sanofi-aventis.


Net sales by geographical region

euro million Q1 2006 Change on a
Net sales comparable basis
Europe 3,168 +5.3%
United States 2,347 -0.5%
Other countries 1,520 +13.4%
TOTAL 7,035 +4.9%


In Europe, net sales advanced by 5.3%, with particularly good performances in the United Kingdom and Italy. In France, sales were adversely affected by new government measures (removal of products from reimbursement lists, price cuts, incentives designed to promote generics, and higher duties on prescription medicines), and this dragged down growth for the Europe region as a whole.
In the United States, net sales were down by 0.5%, a figure which includes the effect of generics competition on 4 products. Excluding the impact of these 4 products(2) on net sales, growth in the United States would have been 16.1%.
Growth in other countries reached 13.4%, with strong contributions coming from Latin America and Asia.
Developed sales
Developed sales give an indication of the overall presence of sanofi-aventis products in the market. 2006 first-quarter developed sales reached euro 7,942 million, up 6.8%.
Developed sales of Plavix(R)/Iscover(R):

euro million Q1 2006 Change on a
comparable basis
Europe 425 +16.1%
United States 713 +27.3%
Other countries 165 +19.6%
TOTAL 1,303 +22.5%


First-quarter developed sales of Plavix(R) were up 22.5% to euro 1,303 million. In the United States, growth in total prescriptions (TRx) of Plavix(R) in the first quarter was 14.2%(6). Product sales in the United States were lifted by the launch late in 2005 of a new promotional campaign aimed at general practitioners, and by a stepping-up of product promotion in hospitals.
Plavix(R) is due to be launched in Japan in May 2006, as a treatment for the reduction of recurrence after ischemic cerebrovascular disorder.
The EMEA and the FDA are currently reviewing an application for Plavix(R) in acute ST-segment elevation myocardial infarction, based on the results of the COMMIT and CLARITY studies.
Developed sales of Aprovel(R)/Avapro(R)/Karvea(R):

euro million Q1 2006 Change on
comparable basis
Europe 213 +16.4%
United States 117 +36.0%
Other countries 84 +13.5%
TOTAL 414 +20.7%


First-quarter developed sales of Aprovel(R)/Avapro(R)/Karvea(R) totaled euro 414 million, a rise of 20.7%.
In the United States, first-quarter sales growth reached 36%, mainly due to lower rebates than in the first quarter of 2005. Total prescriptions rose by 6.0%(6) in the quarter.
(6) IMS NPA 3 channels-YTD 2006


Comments by product

Geographical split of consolidated net sales by product (TOP 15)

Q1 2006 Europe Change on USA Change on Other Change on
net sales a comparable a comparable countries a comparable
(euro million) basis basis basis

Lovenox(R) 173 +6.1% 391 +19.9% 60 +27.7%
Plavix(R) 411 +19.5% 61 +15.1% 108 +31.7%
Stilnox(R)/
Ambien(R)/
Ambien CR(TM) 24 -11.1% 394 +13.5% 23 +15.0%
Taxotere(R) 175 +17.4% 176 +0.6% 79 +25.4%
Eloxatin(R) 145 +13.3% 244 +11.4% 40 +53.8%
Lantus(R) 129 +48.3% 224 +34.1% 29 +93.3%
Copaxone(R) 66 +24.5% 184 +36.3% 13 -
Aprovel(R) 200 +16.3% - - 48 +14.3%
Tritace(R) 135 -1.5% 4 +33.3% 96 +6.7%
Allegra(R) 14 +16.7% 83 -71.6% 83 -23.9%
Amaryl(R) 56 -8.2% 3 -94.0% 62 +17.0%
Xatral(R) 63 +12.5% 19 +18.8% 12 +20.0%
Actonel(R) 65 +25.0% - - 24 +20.0%
Depakine(R) 55 -1.8% - - 23 +15.0%
Nasacort(R) 10 - 53 -5.4% 8 -

Net sales of Lovenox(R), the leading low molecular weight heparin on the market, rose by 16.4% to euro 624 million. Growth of the product continues to be driven by the extension of its use in medical prophylaxis. In cardiology, the results of the ExTRACT study, presented at the American College of Cardiology in March 2006, will be filed in the second half of 2006 (prevention of recurrence or death in patients who have experienced myocardial infarction with ST-segment elevation).
Net sales of Ambien(R)/Ambien CR(TM) in the United States advanced by 13.5% to euro 394 million.
In Japan, developed sales of Myslee(R) came to euro 25 million, an increase of 9.6%.
Taxotere(R) recorded another excellent quarterly performance, both in Europe and the "Other countries" region. In the United States, the product is still facing a tough competitive environment.
In March 2006, Taxotere(R) was approved in the United States for advanced- stage stomach cancer in association with the standard treatment (cisplatin and 5-fluorouracil), and received a positive opinion from the Committee for Human Medicinal Products (CHMP) in Europe in the same indication. Filing for FDA and EMEA approval for Taxotere(R) as a neoadjuvant treatment of head and neck cancer is in progress.
Eloxatin(R), with net sales of euro 429 million, confirmed its status as the leading treatment for colorectal cancer. The take-up rate for the solution ready to use has reached 100% in France and 90% in the United States. This new formulation is currently being launched in a number of other European countries.
Lantus(R), the world's leading insulin brand, continues to record excellent performances, with net sales up 42.0% at euro 382 million. The results of the LANMET study, published in Diabetologia in March 2006, confirmed the benefits of Lantus in association with metformin over the combination of NPH insulin + metformin in patients with type II diabetes. Apidra(R), a new rapid-acting insulin analog for the treatment of type I and type II diabetes, and usable with OptiClick(R), has been on sale in the United States since the end of February 2006. Apidra(R) is an excellent complement to Lantus(R) in therapeutic regimens combining a basal insulin with a rapid- acting analog.
2006 first-quarter adjusted consolidated income statement (unaudited)

The adjusted consolidated income statement is presented in Appendix 3.
Refer to Appendix 1 for definitions of "adjusted net income", and to Appendix 4 for a reconciliation of the consolidated income statement to the adjusted consolidated income statement.
First quarter of 2006 (compared to adjusted first quarter of 2005)
Net sales generated by sanofi-aventis in the first quarter of 2006 were euro 7,035 million, up 9.6% on a reported basis.
Gross profit was euro 5,457 million, 10.0% higher than in the first quarter of 2005. The gross margin ratio rose by 0.3 of a point to 77.6%, compared to 77.3% for the first quarter of 2005, thanks to an increase of 18.9% in other revenues. Despite the impact of generics of Allegra(R), Amaryl(R), Arava(R) and DDAVP(R), the ratio of cost of sales to net sales was unchanged.
Research and development expenses were 13.3% up on the first quarter of 2005 at euro 1,046 million. This rise reflects increasing Phase III clinical trials activity in pharmaceuticals and greater investment in R&D in the vaccines business. Research and development expenses represented 14.9% of net sales, compared to 14.4% in the first quarter of 2005.
Selling and general expenses rose by 6.8% relative to the first quarter of 2005 to euro 2,050 million, representing 29.1% of net sales. Selling expenses rose sharply, but general expenses were lower year-on-year.
Operating income -- current was 12.9% higher at euro 2,419 million and represented 34.4% of net sales, a 1-point improvement on the 2005 first- quarter figure.
Other operating income and expenses came to euro 533 million, against euro 17 million in the first quarter of 2005. The 2006 figure includes gains on disposals of euro 550 million, including euro 461 million on Exubera(R) (euro 384 million after tax) and euro 45 million on the sale of the remaining 30% of the Animal Nutrition business.
Operating income was up 37.4% at euro 2,951 million.
Net financial expense came to euro 30 million, against euro 106 million in the first quarter of 2005. This substantial fall was mainly attributable to a reduction in total debt due to the cash flow generated by the Group. Interest expense on debt totaled euro 73 million, compared to euro 129 million in the first quarter of 2005.
Net financial expense also benefited from net gains on financial instruments (euro 37 million, vs. euro 10 million in the first quarter of 2005).
Income tax expense came to euro 832 million, against euro 650 million for the first quarter of 2005, giving an effective tax rate of 28.5%, against 31.8% for the first quarter of 2005. Excluding the gain on the disposal of Exubera(R), the effective tax rate for the quarter was 30.7% (2005: 31.8%).
The share of profit from associates was euro 181 million, against euro 107 million in the first quarter of 2005. The sharp rise in this item was due to strong growth in the Group's share of after-tax profits from the territories managed by BMS under the Plavix(R) and Avapro(R) alliance (euro 113 million, vs. euro 80 million in the first quarter of 2005), and to an increase in the contribution from Merial.
Minority interests amounted to euro 97 million, compared with euro 83 million in the first quarter of 2005. This line includes the share of pre-tax profits paid over to BMS from territories managed by sanofi-aventis (euro 94 million vs. euro 69 million in the first quarter of 2005).
Net income was 53.6% higher at euro 2,173 million.
Excluding selected items in the first quarter of 2005 and first quarter of 2006 (in 2006, these include the euro 384 million post-tax gain on the sale of Exubera(R), see Appendix 5), adjusted net income would have risen by 20.4%.
Earnings per share (EPS) was euro 1.62, 52.8% up on the 2005 first-quarter figure of euro 1.06, based on an average number of shares outstanding of 1,344.4 million in the first quarter of 2006 and 1,334.6 million in the first quarter of 2005.
Excluding selected items in the first quarter of 2005 and first quarter of 2006 (see Appendix 5), EPS would have risen by 19.8%.
Net debt, which stood at euro 9.9 billion at December 31, 2005, amounted to euro 8.1 billion at March 31, 2006. This figure takes account of the proceeds from the sale of Exubera(R) and the acquisition of a 24.9% interest in Zentiva.
2006 FULL-YEAR OUTLOOK
Our good first-quarter results confirm the 2006 full-year guidance announced on February 24, 2006:
Barring major adverse events, sanofi-aventis expects full-year adjusted EPS growth for 2006 to be in the region of 10%:
-- despite the full-year impact of the availability of generics of
Allegra(R), Amaryl(R), Arava(R) and DDAVP(R) in the United States;
-- after taking account of the substantial launch costs of Plavix(R) in
Japan and Rimonabant(R);
-- assuming after-tax selected items(3) of euro 300 million, compared to
after-tax selected items of euro 168 million in 2005;
-- based on an exchange rate of euro 1:$1.25, with sensitivity to the
euro/dollar exchange rate estimated at 0.6% of growth for a 1-cent
movement in the exchange rate.

Recent events

February 28, 2006 Announcement of the U.S. launch of Apidra(R), a new
rapid-acting insulin analog
March 12, 2006 Presentation to the American College of Cardiology of
the results of the CHARISMA study
March 12, 2006 Presentation to the American College of Cardiology of
the results of the TALISMAN study, demonstrating the
benefits of NV1FGF in patients with critical ischemia
of the lower limbs
March 14, 2006 Presentation to the ACC of the results of the EXTRACT
study, demonstrating the superiority of a strategy
using Lovenox(R) over a non-fractioned heparin in
preventing recurrence of myocardial infarction
March 21, 2006 Announcement by sanofi-aventis and Bristol-Myers
Squibb of agreement with Apotex to settle the patent
infringement lawsuit between the parties in the U.S.
District Court for the Southern District of New York.
The lawsuit relates to the validity of a composition
of matter patent for Plavix(R) (the '265 patent) in
the United States. This agreement is subject to
certain conditions, including antitrust review and
clearance by the Federal Trade Commission and the
State Attorneys General. There is a significant risk
that antitrust clearance will not be obtained, in
which case the proposed settlement would be
terminated and the litigation would be reinstated in
the same Court
March 23, 2006 Announcement of FDA approval for Taxotere(R) in
advanced stomach cancer
March 24, 2006 Announcement of a positive opinion from the Committee
for Human Medicinal Products (CHMP) for Taxotere(R)
in metastatic stomach cancer
March 26, 2006 Announcement by Sanofi Pasteur MSD of a positive
opinion from the Committee for Medicinal Products for
Human Use (CHMP) for Zostavax(R), a vaccine against
herpes zoster (shingles) and herpes zoster related
postherpetic neuralgia
March 27, 2006 Acquisition of a 24.87% interest in Zentiva
April 10, 2006 Court of Appeal rules in favor of sanofi-aventis in
the Lovenox(R) patent infringement case in the
United States
April 12, 2006 Announcement of the transfer to sanofi-aventis of all
Japanese rights for rimonabant
April 28, 2006 Announcement of a positive opinion from the Committee
for Human Medicinal Products (CHMP) for Acomplia(R)
as an adjunct to diet and exercise for treatment of
obese patients (BMI greater than or equal to
30kg/m2), or overweight patients (BMI > 27 kg/m2)
with associated risk factors such as type 2 diabetes
or dyslipidemia(4)
May 2, 2006 Announcement by Sanofi Pasteur MSD of a positive
opinion from the Committee for Human Medicinal
Products (CHMP) for Rotateq, a vaccine to prevent
pediatric rotavirus gastroenteritis


Financial calendar

May 31, 2006 Annual General Meeting
August 2, 2006 2006 second-quarter sales and results
October 31, 2006 2006 third-quarter sales and results


About sanofi-aventis
Sanofi-aventis is the world's third largest pharmaceutical company, ranking number one in Europe. Backed by a world-class R&D organization, sanofi-aventis is developing leading positions in seven major therapeutic areas: cardiovascular, thrombosis, oncology, metabolic diseases, central nervous system, internal medicine, and vaccines. Sanofi-aventis is listed in Paris (EURONEXT: SAN) and in New York (NYSE:SNY)
Forward-Looking Statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statements are statements that are not historical facts. These statements include financial projections and estimates and their underlying assumptions, statements regarding plans, objectives and expectations with respect to future events, operations, products and services, and statements regarding future performance. Forward-looking statements are generally identified by the words "expect," "anticipates," "believes," "intends," "estimates," "plans" and similar expressions. Although sanofi-aventis' management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of sanofi-aventis, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include those discussed or identified in the public filings with the SEC and the AMF made by sanofi-aventis, including those listed under "Risk Factors " and "Cautionary Statement Regarding Forward-Looking Statements" in sanofi-aventis' annual report on Form 20-F for the year ended December 31, 2005. Other than as required by applicable law, sanofi-aventis does not undertake any obligation to update or revise any forward-looking information or statements.
Contact: Jean-Marc Podvin, 33 1.53.77.42.23, jean-marc.podvin@sanofi-aventis.com
Appendices:

List of appendices:

Appendix 1: Explanatory notes
Appendix 2: 2006 first-quarter net sales by product
Appendix 3: 2006 first-quarter adjusted consolidated financial
statements (unaudited)
Appendix 4: 2006 first-quarter reconciliation of consolidated income
statement to adjusted consolidated income statement
(unaudited)
Appendix 5: Trend in selected items of adjusted net income


Appendix 1: Explanatory notes

Comparable net sales
When we refer to the change in our sales on a "comparable" basis, we mean that we exclude the impact of exchange rate movements and changes in Group structure (acquisitions and divestments of interests in entities and rights to products, and changes in consolidation method for consolidated entities).
For any two periods, we exclude the impact of exchange rates by recalculating sales for the earlier period on the basis of exchange rates used in the later period. We exclude the impact of acquisitions by including sales for a portion of the prior period equal to the portion of the current period during which we owned the entity or product rights based on sales information we receive from the party from whom we make the acquisition.
Similarly, we exclude sales in the relevant portion of the prior period when we have sold an entity or rights to a product.
For a change in consolidation method, the prior period is recalculated on the basis of the method used for the current period.
Reconciliation of 2005 first-quarter reported net sales to 2005 first- quarter comparable net sales
euro million Q1 2005
Q1 2005 reported net sales 6,417
Impact of changes in Group structure (40)
Impact of exchange rates 330
Q1 2005 comparable net sales 6,707


Developed sales
When we refer to "developed sales" of a product, we mean consolidated net sales, excluding sales of products to our alliance partners, but including those that are made through our alliances and are not included in our consolidated net sales (with Bristol-Myers Squibb on Plavix(R)/Iscover(R) (clopidogrel) and Aprovel(R)/Avapro(R)/ Karvea(R) (irbesartan), and with Fujisawa on Stilnox(R)/Myslee(R)). Our alliance partners provide us with information regarding their sales in order to allow us to calculate developed sales.
We believe that developed sales are a useful measurement tool because they demonstrate the overall presence of our products in the market.
Reconciliation of net sales to developed sales:

euro million Q1 2006
Net sales 7,035
Non-consolidated sales of Plavix(R)/Iscover(R),
net of sales of product to BMS 723
Non-consolidated sales of Aprovel(R)/Avapro(R)/Karvea(R),
net of sales of product to BMS 166
Non-consolidated sales of Stilnox(R)/Myslee(R),
net of sales of product to Fujisawa 18
Developed sales 7,942


Adjusted net income
We define "adjusted net income" as accounting net income (determined under IFRS) adjusted to exclude (i) the material impacts of the application of purchase accounting to the acquisition of Aventis by sanofi-aventis and (ii) acquisition-related integration and restructuring costs. Sanofi-aventis believes that eliminating these impacts from net income gives investors a better understanding of the underlying economic performance of the combined Group.
The material impacts of the application of purchase accounting to the acquisition of Aventis by sanofi-aventis are as follows:
-- Charges arising from the remeasurement of Aventis inventories at fair
value, net of tax
-- Amortization/impairment expense generated by the remeasurement of
Aventis intangible assets, net of tax
-- Any impairment charged against the goodwill arising on the
acquisition

Sanofi-aventis also excludes from adjusted net income any integration and restructuring costs that are specific to the acquisition of Aventis by sanofi-aventis.
euro million Q1 2006
Q1 2006 Adjusted
Consolidated financial consolidated financial
statements statements
(unaudited)
Net sales 7,035 7,035
Net income 1,512 2,173
Basic EPS 1.12 1.62

Appendix 2: 2006 first-quarter net sales by product

euro million Q1 2006 Q1 2005 Q1 2005
net sales comparable reported
net sales net sales
Lovenox(R) 624 536 500
Plavix(R) 580 479 468
Stilnox(R)/Ambien(R)/Ambien CR(TM) 441 394 362
Taxotere(R) 430 387 365
Eloxatin(R) 429 373 350
Lantus(R) 382 269 252
Copaxone(R) 263 201 187
Aprovel(R) 248 214 209
Tritace(R) 235 230 218
Allegra(R) 180 413 386
Amaryl(R) 121 164 156
Xatral(R) 94 82 79
Actonel(R) 89 72 80
Depakine(R) 78 76 74
Nasacort(R) 71 74 67
TOTAL 4,265 3,964 3,753
Other products 2,258 2,352 2,304
TOTAL Pharmaceuticals 6,523 6,316 6,057
Vaccines 512 391 360
TOTAL net sales 7,035 6,707 6,417

Appendix 3: 2006 first-quarter adjusted consolidated financial statements (unaudited)
Q1 2006 Q1 2005
Adjusted Adjusted
consolidated consolidated
income income
statement as % of statement as % of %
(unaudited) net sales (unaudited) net sales change
euro million

Net sales 7,035 100.0% 6,417 100.0% +9.6%
Other revenues 289 4.1% 243 3.8% +18.9%
Cost of sales (1,867) 26.5% (1,697) 26.5% +10.0%
Gross profit 5,457 77.6% 4,963 77.3% +10.0%
Research and
development
expenses (1,046) 14.9% (923) 14.4% +13.3%
Selling and
general
expenses (2,050) 29.1% (1,920) 29.9% +6.8%
Other current
operating
income 119 - 77 - +54.5%
Other current
operating
expenses (28) - (27) - +3.7%
Amortization of
intangibles (33) - (27) - +22.2%
Operating income -
current 2,419 34.4% 2,143 33.4% +12.9%
Restructuring
costs - - (13) - -
Impairment of
PP&E and
intangibles (1) - - - -
Other operating
income and
expenses 533 - 17 - -
Operating income 2,951 41.9% 2,147 33.5% +37.4%
Financial
expenses (109) - (162) - -32.7%
Financial income 79 - 56 - +41.1%
Income before tax
and associates 2,921 41.5% 2,041 31.8% +43.1%
Income tax
expense (832) 11.8% (650) 10.1% +28.0%
Effective
tax rate 28.5% - 31.8% - -
Share of profit/
loss of
associates 181 - 107 - +69.2%
Net income before
minority
interests 2,270 32.3% 1,498 23.3% +51.5%
Minority
interests (97) - (83) - +16.9%
Net income 2,173 30.9% 1,415 22.1% +53.6%
Average number
of shares
outstanding
(m) 1,344.4 1,334.6
Earnings per share
(in euros) 1.62 1.06 +52.8%

Appendix 4: 2006 first-quarter reconciliation of consolidated income statement to adjusted consolidated income statement (unaudited)
The adjustments to the income statement reflect the elimination of material impacts of the application of purchase accounting to the Aventis acquisition (euro 629 million net of deferred taxes, with no cash impact for the Group) and restructuring charges (euro 32 million net of tax), i.e. a total impact of euro 661 million.
euro million Q1 2006 Q1 2006
Consolidated Adjustments Adjusted
(unaudited) consolidated
(unaudited)
Net sales 7,035 7,035
Other revenues 289 289
Cost of sales (1,873) 6 (a) (1,867)
Gross profit 5,451 6 5,457
Research and development
expenses (1,046) (1,046)
Selling and general expenses (2,050) (2,050)
Other current operating income 119 119
Other current operating expenses (28) (28)
Amortization of intangibles (1,000) 967 (b) (33)
Operating income - current 1,446 973 2,419
Restructuring costs (48) 48 (c) -
Impairment of PP&E and
intangibles (1) (1)
Other operating income and
expenses 533 533
Operating income 1,930 1,021 2,951
Financial expenses (109) (109)
Financial income 79 79
Income before tax and
associates 1,900 1,021 2,921
Income tax expense (451) (381) (d) (832)
Share of profit/loss of
associates 160 21 (e) 181
Net income before minority
interests 1,609 661 2,270
Minority interests (97) (97)
Net income 1,512 661 2,173
Average number of
shares outstanding (m) 1,344.4 1,344.4
Earnings per share (in euros) 1.12 0.50 1.62


The material impacts of the application of purchase accounting to the Aventis acquisition and of restructuring charges on the 2006 first-quarter consolidated income statement are as follows:
(a) A charge of euro 6 million arising from the workdown of acquired
inventories remeasured at fair value. This adjustment has no cash
impact on the Group.
(b) An amortization charge of euro 967 million against intangible assets.
This adjustment has no cash impact on the Group.
(c) A pre-tax restructuring charge of euro 48 million.
(d) The tax impact primarily comprises:

(1) Deferred taxes of euro 365 million generated primarily by the
amortization charge of euro 967 million taken against
intangible assets and by the euro 6 million charge arising
from the workdown of acquired inventories remeasured at fair
value. This adjustment has no cash impact on the Group.

(2) A tax saving of euro 16 million related to the
euro 48 million of restructuring charges.

(e) In "Share of profit/loss from associates", a charge of
euro 21 million corresponding to the amortization of intangibles
(net of tax) and the workdown of acquired inventories. This
adjustment has no cash impact on the Group.


Appendix 5: Trend in selected items of adjusted net income

euro million Q1 2006 Q1 2005
Restructuring costs
(Aventis pre-acquisition programs) - (13)
Net gains on disposals
(including euro 461 million pre-tax
gain on Exubera(R)) 550 7
Provisions for investment portfolio,
financial instruments and other items 30 1
TOTAL before tax 580 (5)
TOTAL after tax 466 (3)


REMINDER

8.00 am CET - WEBCAST
& CONFERENCE CALL (English) The 1st quarter 2006 sales and earnings
will be reviewed at 8.00 am (Paris time)
by Mr. Hanspeter Spek, Executive
Vice-President, Pharmaceutical Operations
and Mr. Jean-Claude Leroy, Executive
Vice-President, CFO. The slides will be
available on
http://www.sanofi-aventis.com. This
presentation will be followed by a Q&A
session.

CALL-IN NUMBERS The conference will also be available by
telephone via the following numbers:

France +33 (0) 1 71 23 04 18
UK +44 (0) 207 138 0835
USA +1 718 354 1172

AUDIO REPLAY Available online at
http://www.sanofi-aventis.com and through
the numbers below (until May 14, 2006):

France +33 (0) 1 71 23 02 48
UK +44 (0) 207 806 1970
USA +1 718 354 1112
Access code 4816521#
Source: Sanofi-aventis

CONTACT: Jean-Marc Podvin of Sanofi-aventis, +33-1-53-77-42-23,
jean-marc.podvin@sanofi-aventis.com