|San Antonio, TX|
|March 22, 2005|
|Latest Findings Presented at AAAAI 61st Annual Meeting|
Researchers conclude that treatment taken once a day with the investigational therapy Alvesco® (ciclesonide) significantly improves quality-of-life compared with placebo in patients with mild-to-moderate asthma. The data were presented at the American Academy of Allergy, Asthma & Immunology (AAAAI) 61st Annual Meeting.
“In addition to conventional indicators of lung function, quality-of-life assessments that provide data on an asthma patient’s daily physical, emotional and social difficulties are an important tool for evaluating response to treatment,” said Anjuli S. Nayak, MD, Assistant Professor in the Department of Pediatrics at the University of Illinois, College of Medicine, and lead investigator of this study. “Our findings, as seen in this study, demonstrate that Alvesco significantly improves the quality-of-life for patients 12 years and older with mild-to-moderate asthma.”
Alvesco is an inhaled corticosteroid with novel release and distribution properties. Inhaled corticosteroids, considered to be the foundation of asthma treatment, work by reducing inflammation – the underlying disease process – in the lungs and airways.
Trial Design and Results
A significant improvement (P<0.0001) in the overall AQLQ score was observed for all CIC groups (CIC80, 0.36; CIC160, 0.47; CIC320, 0.55) versus placebo, from baseline to week 12. A similar trend was observed for all four individual domain scores, except the environmental stimuli domain in the CIC80 group. A change from baseline to week 12 in overall AQLQ score of ≥0.5 MID was noted in a greater proportion of patients in the CIC groups (CIC80, 47%; CIC160, 50%; and CIC320, 50.6%) versus placebo (31%).
Sanofi-aventis is the world’s 3rd largest pharmaceutical company, ranking number 1 in Europe. Backed by a world-class R&D organization, sanofi-aventis is developing leading positions in seven major therapeutic areas: cardiovascular, thrombosis, oncology, metabolic disorders, central nervous system, internal medicine, and vaccines. Sanofi-aventis is listed in Paris (EURONEXT : SAN) and in New York (NYSE : SNY)
The sanofi-aventis Group conducts business in the U.S. through its subsidiaries Sanofi-Synthelabo Inc. and Aventis Pharmaceuticals Inc.
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